Proposed time series for the common processes that drove stream piracy and reorganization of pre-Quaternary drainage patterns in the North American mid-continent to create the modern Ohio (MO) and upper Mississippi (UM) Rivers. (A) Proposed configuration of the ancestral Wyalusing (W), Teays (T), and Pittsburgh (P) Rivers as they evolved prior to Quaternary glaciations. Red dashed line represents the approximate location of the continental drainage divide. (B) Damming of the lower St. Lawrence drainage by early to middle Quaternary glaciation(s) blocked the ancestral Wyalusing River to create the informally named glacial Lake Muscoda (GLMu); the ancestral Teays River to create glacial Lake Tight (GLT); and the ancestral Pittsburgh River to create glacial Lake Monongahela (GLMo). Spill-over of the lakes at the lowest drainage divides (red diamonds) initiated reorganization of river systems. (C) Modern drainage configuration, with continental drainage divide (red dashed line) moved northward as drainage capture diverted river systems away from the Gulf of St. Lawrence and toward the Gulf of Mexico. UO—upper Ohio River.